Lisdexamfetamine 

Overview

lisdexamfetamine is a novel extended-release version of dextroamphetamine. The prolonged release is accomplished by modifying the active molecule dextroamphetamine to form lisdexamfetamine, which is ineffective. After taking Lisdexamfetamine  , it is quickly absorbed and it is metabolized by the liver back into the potent stimulant dextroamphetamine. The time required to absorb and convert Lisdexamfetamine   is basically an extended-release dextroamphetamine formulation due to the addition of lisdexamfetamine. Upon activation, Lisdexamfetamine   is comparable to Dexedrine Spansules (dextroamphetamine extended-Release capsules) and has an 8–12-hour duration of action.
Labeled usage refers to using a medicine for its authorized indications. In clinical practice,
Physicians often prescribe drugs for unlabeled (“off-label”) applications when published clinical research, case reports, or their own clinical experiences, provide evidence of the therapy’ effectiveness and safety. Lisdexamfetamine   is authorized FDA-approved therapy for attention deficit/hyperactivity disorder (ADHD). However, physicians may use it to treat narcolepsy, a disorder characterized by daytime somnolence in which a person goes into a deep slumber throughout the day. Because Lisdexamfetamine   is a stimulant, it is a tightly restricted chemical. The doctor must write A fresh prescription is issued each time it is dispensed, and it cannot be refilled.

Dosing Information

The dose of Lisdexamfetamine   varies with age, weight, and response. Because Lisdexamfetamine   was examined mainly in adults, it has limited access to dosage information for ADHD children.
The suggested beginning dose in children aged 6 to 12 years with ADHD who are either starting treatment for the first time or moving from another medicine is 30 mg per day in the morning, given with or without food. If necessary, the dose may be raised by 20 mg/day at weekly intervals. The highest suggested dose for children is 70 mg per day. The dose for adults may differ.

Common Side Effects

The negative effects described with Lisdexamfetamine   are mostly from early clinical investigations of children aged 6 to 12 years. More common adverse effects include headaches, reduced appetite, weight loss, sleeplessness, irritability, and abdominal discomfort. Sometimes these adverse effects are induced by beginning the medicine at too high a dose.

They should subside when the dose is reduced. Overall, adverse effects grow less troublesome as patients get acclimated to the medication.

Adverse effects and precautions

Lisdexamfetamine  , like other amphetamines, has a significant potential for abuse. People with a history of alcohol Substance abusers may be more likely to misuse stimulants. People who misuse Lisdexamfetamine   acquire tolerance and psychological dependency, which may lead to addiction.

Lisdexamfetamine   may cause elevated blood pressure and heart rate. Patients with a history of hypertension or heart disease should exercise caution while using Lisdexamfetamine   since it may worsen these issues. Uncontrolled High blood pressure may lead to major complications, such as a stroke or heart attack. Patients on Lisdexamfetamine   should regularly check their blood pressure.

Individuals with a history of seizure disorder should be careful when using Lisdexamfetamine  . It may reduce the seizure threshold and increase vulnerability to seizures.

Lisdexamfetamine   may inhibit linear growth in children and teenagers. Physicians sometimes halt therapy on weekends and holidays when children are not in school, for development.
Children and adolescents on Lisdexamfetamine   need regular monitoring for growth suppression, as well as frequent height measurements. This impact is not of concern in the adult population.
Lisdexamfetamine   may exacerbate tics in those with a tic condition (i.e., twitching of a muscle group, particularly In the face). Lisdexamfetamine   should be avoided or taken with care in those who have schizophrenia or bipolar illness. Stimulants are often overused in this community, and large doses of Lisdexamfetamine   may cause psychosis and mania.

Use in Pregnancy and Breastfeeding: Category C.

Lisdexamfetamine   has not been studied in women to verify its safety during pregnancy. The medication’s impact on the growing fetus is unknown. Women who are pregnant or may become pregnant should talk about this with their physician.

Nursing women should not use any stimulants since tiny doses will pass into breast milk and be swallowed by the infant. If discontinuing the stimulant is not an option, breastfeeding should not be started or Should be terminated.

Possible Drug Interactions

Lisdexamfetamine   should not be used in conjunction with antidepressants called monoamine oxidase inhibitors(MAOIs). The combination may cause elevated blood pressure. This and other notable medication interactions. The activities reported with Lisdexamfetamine   are summarized in the following. 

• MAOIs shouldn’t be used with methylphenidates. Concerta, Ritalin, Focalin, and dextroamphetamine (such as DextroStat, Adderall, and Adderall XR) Or Strattera. The combination may precipitate. High blood pressure is a serious concern. 
• Weight-loss drugs (e.g., Meridia) Weight-loss drugs, both prescription and non- Prescription medication should not be used with dextroamphetamines/amphetamines or methylphenidates. The combination may elevate blood pressure and induce irritation, sleeplessness, and other unpleasant effects to extreme stimulation.

Overdose

The severity of Lisdexamfetamine   overdose is determined on the quantity eaten. Symptoms of an acute overdose may include restlessness, agitation, irritability, sleeplessness, hyperactivity, disorientation, high blood pressure, fast heart rate, psychosis, hallucinations, irregular pulse, and convulsions, Coma, cardiovascular collapse, and death.

Any suspected overdose should be considered an emergency. The individual should be rushed to the emergency. There is space for observation and therapy. The prescription bottle of medicine (and any additional drug implicated in the overdose) should also be presented, since the information on the prescription label is beneficial to the treating physician in knowing the number of tablets consumed.

Special Considerations

• Lisdexamfetamine   is only taken once each day, usually in the morning. If you miss a dosage, take it right away. If it is late afternoon, skip the pill and resume your usual dosage the following morning. Taking the medicine too late in the afternoon may make sleeping difficult. To prevent insomnia, use Lisdexamfetamine   in the morning.
• The pill should be swallowed whole. It may also be opened and the contents poured into a glass of water and eaten immediately.
• Lisdexamfetamine   may be taken with or without meals.
• Do not take more than prescribed by your doctor.
• If Lisdexamfetamine   causes significant agitation, restlessness, sleeplessness, lack of appetite, or weight loss, inform Your physician.
• Keep the medicine in the original labeled, light-resistant container, away from heat and moisture. Heat Moisture may promote the breakdown of your drug, causing it to lose its therapeutic effects, and the medicine may lose its therapeutic efficacy.
• Keep your prescriptions out of reach of youngsters.