Dextroamphetamine 

Overview 

DextroStat (immediate-release dextroamphetamine) and Dexedrine Spansules (dextroamphetamine) Sustained-release capsules are psychostimulants, also known as stimulants. Dextroamphetamine is generally used to treat attention-deficit/hyperactivity disorder (ADHD) and narcolepsy, which is characterized by daytime somnolence occurs when the patient occasionally slips into a deep slumber throughout the day. Narcolepsy is a disorder. The sequence of sleep-wake regulatory processes inside the brain that interferes with both daytime wakefulness and Nighttime slumber.

Labeled usage refers to using a medicine for its authorized indications. In clinical practice, however, doctors often prescribe drugs for unlabeled (“off-label”) applications when publishing clinical research, case reports. Alternatively, their own clinical experiences confirm the effectiveness and safety of the therapy. Dextroamphetamine is often used to supplement antidepressants for resistant depression. For individuals undergoing continuous treatment for example, in resistant depression, dextroamphetamine in conjunction with antidepressants may give symptomatic relief and improvement that exceeds that of antidepressants alone.

Numerous clinical research and decades of clinical experience have convincingly established that dextroamphetamine improves outcomes for children with ADHD. Dextroamphetamine improves the child’s capacity to focus, increases attention span, and reduces hyperactivity. Adults with ADHD may benefit from treatment with dextroamphetamine. Dextroamphetamine allows people to concentrate and stay focused on them tasks, improves attention span, and reduces impulsivity and hyperactivity. Because DextroStat and Dexedrine Spansules are stimulants, they are strictly regulated drugs. Every time a prescription is delivered, the physician must write a new one, and it cannot be renewed.

Dosing Information

Dextroamphetamine is marketed as immediate-release tablets (DextroStat) and sustained-release capsules (Dexedrine Spansules). Adults should start with 5 mg of dextroamphetamine twice a day. The dose is changed according to the individual’s response. The normal therapeutic dose range is approximately 10 mg per day and 40 mg/day, given twice daily. Dosing dextroamphetamine for instant release, the form may be changed to once-daily administration using an equal dose of sustained-release capsules.

Common Side Effects

The most frequent adverse effects of using dextroamphetamine include fast heart rate, palpitations, anxiety, restlessness, sleeplessness, dry mouth, constipation, nausea, diarrhea, lack of appetite, weight loss, and elevation of blood pressure.

Adverse effects and precautions

Dextroamphetamine has a significant risk of misuse. Individuals with a history of alcohol and drug abuse, they may be at danger of misusing stimulants. Individuals who misuse dextroamphetamine acquire tolerance and psychological reliance, which may lead to addiction. With long-term usage of dextroamphetamine as a consequence of restless nights, the person may acquire psychotic symptoms.

Dextroamphetamine may raise blood pressure. Individuals having a history of high blood pressure. People with heart illness should exercise caution while using dextroamphetamine since it might aggravate their symptoms. Uncontrolled high blood pressure may lead to significant complications, such as a stroke or heart attack. Patients who use dextroamphetamine should monitor their blood pressure on a regular basis.
Individuals with a history of seizure disorder should be careful while using dextroamphetamine, because it may reduce the seizure threshold and increase vulnerability to seizures. Dextroamphetamine has been shown to decrease linear development in children and adolescents’ growth. Physicians often suspend therapy on weekends and holidays when children are not in school for growth catch-up. Children and teenagers who use dextroamphetamine need strict supervision for growth inhibition and periodic height measurement. This impact is not of concern in the adult population.

Dextroamphetamine may exacerbate tics in persons with a tic condition (i.e., muscular twitching particularly in the face). Dextroamphetamine should be avoided, or taken with care, by people diagnosed with schizophrenia or bipolar disorder. In this demographic, stimulants are widely misused, particularly large doses of dextroamphetamine may cause psychosis and mania.

Use in Pregnancy and Breastfeeding: Category C

Dextroamphetamine has not been studied in women to confirm its safety during pregnancy. Effects of the Medication’s effects on the growing fetus in pregnant women are unclear. Women who are expecting or may Become pregnant, should consult with their doctor.

Nursing women should not use any stimulants since tiny doses will pass into breast milk and be swallowed by the infant. If discontinuing the stimulant is not an option, breastfeeding should not be started or Should be terminated.

Possible Drug Interactions
Dextroamphetamine should not be used with monoamine oxidase inhibitors, a kind of antidepressant. The combination may cause elevated blood pressure. This and Other notable medication interactions documented with dextroamphetamine are shown below.

•  MAOIs shouldn’t be used with methylphenidates. Concerta, Ritalin, Focalin, and dextroamphetamine amines (such as DextroStat, Adderall, and Adderall XR) Or Strattera. The combination may precipitate. High blood pressure is a serious concern.
• Weight-loss drugs (e.g., Meridia) Weight-loss drugs, prescription and Non-prescription and should not be used with Dextroamphetamine/amphetamines or methylphenidates. This combination may Increase blood pressure or create irritation, Insomnia and other side effects from Excessive stimulation.

Overdose

The severity of dextroamphetamine overdose varies with the quantity consumed. An person may experience Restlessness, anxiety, irritability, and sleeplessness are symptoms that escalate from an acute overdose, Hyperactivity, disorientation, increased blood pressure, fast heart rate, psychosis, hallucinations, irregular pulse, Convulsions, coma, cardiovascular collapse, and death.

Any suspected overdose should be considered an emergency. The individual should be rushed to the emergency. There is space for observation and therapy. The prescription bottle of medicine (and any additional drug implicated in the overdose) should also be presented, since the information on the prescription label is beneficial to the treating physician in knowing the number of tablets consumed.

Special Considerations

• To prevent sleeplessness, do not take the final dosage of dextroamphetamine late in the evening. Dexedrine Spansules should be taken one daily in the morning.
• Dextroamphetamines may be taken with or without meals.
• Do not take more than prescribed by your doctor.
• If dextroamphetamine produces intense agitation, restlessness, sleeplessness, lack of appetite, or weight Please contact your doctor if you have lost anything.
• If you miss a dosage, take it right away. If it is near to the next scheduled dosage, skip the missed one. Continue with your normal dose regimen. Do not take two doses. If you missed your dosage of Dexedrine Spansules in the morning and it is late in the evening, skip the dose and continue with your usual dosing schedule for the following morning.
• Dextroamphetamine pills should not be chewed or crushed; instead, consume them whole. Drink with a full glass of water assists in swallowing the medicine.
• Keep the medicine in the original labeled, light-resistant container, away from heat and moisture. Heat Moisture may promote the breakdown of your drug, causing it to lose its therapeutic effects.
• Keep your medications out of reach of youngsters.